A Patient With Sars-Cov-2 Infection During Pregnancy In Qingdao, China

Original Article: Rong Wen, Yue Sun, Quan-Sheng Xing, A patient with sars-cov-2 infection during pregnancy in Qingdao, China, Journal of Microbiology, Immunology and Infection

Author of summary: Elisabetta Canitano; Reviewer: Daria Di Filippo

Original Article Published on March 10th, 2020

Clinical case of a pregnant woman visited at 30 weeks of gestational age with mild diarrea, after 13 days from having been in contact with her relatives living in Hubei. Initially treated with supportive therapy, she was then given Interferon and Lopinavir/Ritonavir once diagnosed with COVID-19 through RT-PCR and CT scan. Discharged after 16 days at recovery, with negative swabs and CT scan, and a physiological progression of her pregnancy.

On Feb 4, a 31-year-old female at 30 weeks gestation presented with mild diarrhea. She was afebrile, breathing normally, and did not have cough or chest pain. She was on self-isolation at home since Jan 23, as on Jan 22, she had visited her mother and brother, living in Hubei (confirmed SARS-CoV-2 infection on Feb 3 and 4, respectively). Based on this contact history, SARS-CoV-2 RT-PCR tests were performed on Feb 5. Nasopharyngeal swabs and sputum resulted positive. On Feb 7, chest CT images showed multiple regions of patchy consolidation and ground glass opacities with indistinct border in the bilateral lower lungs and left upper lung. The lesions were distributed along the bronchial bundles or within the subpleural lung regions, and a little amount of pleural fluid was found on left chest. No lymphadenopathy was found. Combining PCR and CT results, she was diagnosed as pregnancy with COVID-19. On Day 2 of hospitalization, the patient received supportive therapies, whereas aerosolized interferon inhalation (5,000,000 IU bid) and Lopinavir/Ritonavir (2 tablets bid) were added from Feb 7. On Feb 11, CT showed a significant resolution of the initial lung abnormalities. On Feb 13, two nasopharyngeal swabs were negative on RT-PCR, but on Feb 14, her sputum was positive. From Feb 16 to Feb 19, her nasopharyngeal swabs and sputum, performed every 24 h, were all negative. She made a recovery and was discharged on Feb 20. The fetus developed normally; we will follow up the labour and the outcome of the fetus. From the recently published literature, pregnant women with COVID-19 showed a similar pattern of clinical characteristics to non-pregnant adult patients, including a fever and cough, less diarrhea and shortness of breath. The symptom in our case was mild diarrhea, which shouldn’t be ignored in the clinical management of pregnant women.

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