The term “exposome” refers to the whole range of exposures to which an organism is subjected from its birth, including environmental and lifestyle habits, such as nutrition or smoking. Understanding the relationship between human body and the totality of exposures to which it is subjected, could complement genetic information, explaining the origins of some chronic disease and provide the basis for the development of new strategies of prevention and/or protection.
Increasing attention is being paid to the exposome of human skin: as a barrier organ, skin is exposed to a huge variety of environmental factors.
Focusing on a non-pathologic trait, and basing on an article published by Krutmann in 2017, this paper provides an overview of the most relevant factors contributing to skin aging. These includes sun radiation, pollution, cigarette smoke, nutrition, stress, temperature, sleep deprivation, and the use of cosmetics.
Despite the importance of skin exposome, further efforts are required to better understand the role of each factors and how these factors can interact in order to develop new anti-aging strategies.